Post-translational modification of a peptide has been linked to many biological functions and cellular processes, such as protein degradation, signaling and regulatory processes, regulation of gene expression, and protein-protein interactions. 

 

Crefu Peptides has a extensive experience in the synthesis of below listed post-translationally modified peptides:

Arginine Methylation Peptide Modifications

Arginine methylated are involved in a number of different cellular processes, including transcriptional regulation, RNA metabolism and DNA damage repair. Their respective structures are shown as below:
 

Lysine methylation is restricted to a subset of proteins and catalysed by highly specific methyltransferases that can generate mono-, di-, and trimethylated lysines. These modifications result in changes in protein : protein interactions, chromatin structure and gene expression. Their respective structures are shown as below:

Glycopeptides Modifications
 

Glycosylation is one of the most common post-translational modifications of proteins, with significant effects on protein folding, conformation, distribution, stability and activity.

 

N-linked glycosylation
 

N-linked glycosylation are covalently attached to protein at asparagine (Asn) residues by an N-glycosidic, and is important for both the structure and function of some eukaryotic protein.

 

O-linked glycosylation
 

O-Linked glycosylation are form by a linkage between an amino acid hydroxyl side chain (usually from serine or threonine) with the glycan. The majority of O-linked glycans take the form GlcNac-β-Ser/Thr or GalNac-α-Ser/Thr.

Other PTMs
 

Myristoylation, Palmitoylation, Pyroglutamate（Pyr), Proline hydroxylation(Hyp).